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    <ns1:donorDNA>Bacteriophage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Rnf2 genomic DNA</ns1:donorDNA>
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    <dc:description xml:lang="ja">Ring1Bは、ポリコム群抑制性複合体１ (PRC１) に含まれる触媒サブユニットであり、ヒストンH2aリシン119のモノユビキチン化のためのE3リガーゼとして機能する。このコンディショナルアリルでは、RINGフィンガーのN端側にある約50アミノ酸をコードするエキソンが欠損し、触媒活性を失ったRing1Bが発現される。</dc:description>
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    <ns1:colonyMaintenance xml:lang="ja">C57BL/J (日本クレア) に戻し交配5回後、兄妹交配で維持。</ns1:colonyMaintenance>
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    <skos:altLabel xml:lang="en">B6-Rnf2 floxed Ring1B cond</skos:altLabel>
    <skos:altLabel xml:lang="ja">B6-Rnf2 floxed Ring1B cond</skos:altLabel>
    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr05572'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
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    <ns1:strainDevelopment xml:lang="en">Developed by Haruhiko Koseki, RIKEN Center for Allergy and Immunology, and Miguel Vidal, Centro de Investigaciones Biologicas in 2002. R1 ES cells derived from (129X1/SvJ x 129S1/Sv)F1-Kitl&lt;+&gt; were used. The mutant mice were crossed to C57BL/6J at least 5 times.</ns1:strainDevelopment>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/15525528"/>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;利用者が本件リソースを使用して得られた研究成果に基づき特許等の申請、及び事業活動を行う場合は、寄託者と別途協議を行う。</ns4:termsAndConditions>
    <ns6:brs_depositor xml:lang="ja">古関　明彦</ns6:brs_depositor>
    <ns6:brs_depositor xml:lang="en">Haruhiko KOSEKI</ns6:brs_depositor>
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    <ns4:termsAndConditions xml:lang="en">The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.</ns4:termsAndConditions>
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    <dc:description xml:lang="en">Ring1B (Rnf2) gene floxed mice. A loxP site was inserted upstream of Exon 2 including the ATG codon. A floxed neo cassette was inserted into intron 2.</dc:description>
    <ns1:colonyMaintenance xml:lang="en">Heterozygote x Wild-type [C57BL/6JJcl]</ns1:colonyMaintenance>
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    <rdfs:label xml:lang="en">B6;129-Rnf2&lt;tm2Hko&gt;</rdfs:label>
    <rdfs:label>B6;129-Rnf2&lt;tm2Hko&gt;</rdfs:label>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
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    <ns1:strainDevelopment xml:lang="ja">理化学研究所 古関 明彦先生 CSIC Miguel Vidal (2002年)RI (129) ES細胞を用いて作出。</ns1:strainDevelopment>
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    <ns4:application>Cre/loxP system</ns4:application>
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    <dcterms:identifier>RBRC05572</dcterms:identifier>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
    <ns1:strainDevelopment xml:lang="ja">理化学研究所 古関 明彦先生 CSIC Miguel Vidal (2002年) RI (129) ES細胞を用いて作出。</ns1:strainDevelopment>
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    <ns11:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/15525528"/>
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    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_3"/>
    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <ns1:ESCellLine>R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl&lt;+&gt;]</ns1:ESCellLine>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_6"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015493">
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_17432">
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RecoveryTestResult_1374">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC05572"/>
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